Data Mining Techniques for Extraction and Analysis of Covid-19 Data

Artificial intelligence has played a crucial role in medical disease diagnosis. In this research, data mining techniques that included deep learning with different scenarios are presented for extraction and analysis of covid-19 data. The energy of the features is implemented and calculated from the CT scan images. A modified meta-heuristic algorithm is introduced and then used in the suggested way to determine the best and most useful features, which are based on how ants behave. Different patients with different problems are investigated and analyzed. Also, the results are compared with other studies. The results of the proposed method show that the proposed method has higher accuracy than other methods. It is concluded from the results that the most crucial features can be concentrated on during feature selection, which lowers the error rate when separating sick from healthy individuals. © 2022 IEEE.

Choosing the Right Tool for the Job: Screening Tools for Systematic Reviews in Education

In recent years, the rapid development of artificial intelligence has enabled the launch of many new screening tools. This review aims to facilitate screening tool selection through a systematic narrative review and feature analysis. The current adoption rate of transparent tool reporting is low: by screening 191 studies published in the Review of Educational Research since 2015, we found that only eight studies reported screening tools. More research is needed to understand the reasons behind this phenomenon. After consulting various sources, 26 available screening tools in the market were found. Among them, we identified and evaluated 12 screening tools for educational reviewers and ranked them in descending order of feature score: Covidence (1), DistillerSR (2, tied), EPPI-Reviewer (2, tied), CADIMA (4), Swift-Active (5), Rayyan (6, tied), SysRev (6, tied), Abstrackr (8, tied), ReLiS (8, tied), RevMan (8, tied), ASReview (11), and Excel (12). In the discussion, we provide insights into the promise and bias in tools' machine learning algorithms. Our results encourage researchers to report their tool usage in publications and select tools based on suitability instead of convenience. © 2023 Taylor & Francis Group, LLC.

Gabor Filter-Based Caries Image Feature Analysis Using Machine Learning

Dental caries sufferers in Indonesia demonstrate a higher frequency than other dental diseases even before the Covid-19 pandemic. The high risk of spreading the virus during the pandemic hinders handling dental care patients. Teledentistry is suggested as the main alternative to reduce the risk of spreading the virus. This study aims to establish a system for classifying the level of dental caries based on texture applicable for clinical implementation. Dental caries images were extracted using the Gabor Filter method and classified using the Support Vector Machine (SVM) and K-Nearest Neighbor (K-NN). A downsampling technique was applied to this system to reduce the large number of features affecting the classification time. System testing revealed that the Cubic SVM model generated the best result: Accuracy of 90.5%, precision of 89.75%, recall of 89.25%, specificity of 91.75%, and f-score of 88.5%. © 2022 IEEE.

Identifying MicroRNA Markers That Predict COVID-19 Severity Using Machine Learning Methods.

Individuals with the SARS-CoV-2 infection may experience a wide range of symptoms, from being asymptomatic to having a mild fever and cough to a severe respiratory impairment that results in death. MicroRNA (miRNA), which plays a role in the antiviral effects of SARS-CoV-2 infection, has the potential to be used as a novel marker to distinguish between patients who have various COVID-19 clinical severities. In the current study, the existing blood expression profiles reported in two previous studies were combined for deep analyses. The final profiles contained 1444 miRNAs in 375 patients from six categories, which were as follows: 30 patients with mild COVID-19 symptoms, 81 patients with moderate COVID-19 symptoms, 30 non-COVID-19 patients with mild symptoms, 137 patients with severe COVID-19 symptoms, 31 non-COVID-19 patients with severe symptoms, and 66 healthy controls. An efficient computational framework containing four feature selection methods (LASSO, LightGBM, MCFS, and mRMR) and four classification algorithms (DT, KNN, RF, and SVM) was designed to screen clinical miRNA markers, and a high-precision RF model with a 0.780 weighted F1 was constructed. Some miRNAs, including miR-24-3p, whose differential expression was discovered in patients with acute lung injury complications brought on by severe COVID-19, and miR-148a-3p, differentially expressed against SARS-CoV-2 structural proteins, were identified, thereby suggesting the effectiveness and accuracy of our framework. Meanwhile, we extracted classification rules based on the DT model for the quantitative representation of the role of miRNA expression in differentiating COVID-19 patients with different severities. The search for novel biomarkers that could predict the severity of the disease could aid in the clinical diagnosis of COVID-19 and in exploring the specific mechanisms of the complications caused by SARS-CoV-2 infection. Moreover, new therapeutic targets for the disease may be found.

Web-Based Software Tools for Systematic Literature Review in Medicine: Systematic Search and Feature Analysis.

BACKGROUND: Systematic reviews (SRs) are central to evaluating therapies but have high costs in terms of both time and money. Many software tools exist to assist with SRs, but most tools do not support the full process, and transparency and replicability of SR depend on performing and presenting evidence according to established best practices. OBJECTIVE: This study aims to provide a basis for comparing and selecting between web-based software tools that support SR, by conducting a feature-by-feature comparison of SR tools. METHODS: We searched for SR tools by reviewing any such tool listed in the SR Toolbox, previous reviews of SR tools, and qualitative Google searching. We included all SR tools that were currently functional and required no coding, and excluded reference managers, desktop applications, and statistical software. The list of features to assess was populated by combining all features assessed in 4 previous reviews of SR tools; we also added 5 features (manual addition, screening automation, dual extraction, living review, and public outputs) that were independently noted as best practices or enhancements of transparency and replicability. Then, 2 reviewers assigned binary present or absent assessments to all SR tools with respect to all features, and a third reviewer adjudicated all disagreements. RESULTS: Of the 53 SR tools found, 55% (29/53) were excluded, leaving 45% (24/53) for assessment. In total, 30 features were assessed across 6 classes, and the interobserver agreement was 86.46%. Giotto Compliance (27/30, 90%), DistillerSR (26/30, 87%), and Nested Knowledge (26/30, 87%) support the most features, followed by EPPI-Reviewer Web (25/30, 83%), LitStream (23/30, 77%), JBI SUMARI (21/30, 70%), and SRDB.PRO (VTS Software) (21/30, 70%). Fewer than half of all the features assessed are supported by 7 tools: RobotAnalyst (National Centre for Text Mining), SRDR (Agency for Healthcare Research and Quality), SyRF (Systematic Review Facility), Data Abstraction Assistant (Center for Evidence Synthesis in Health), SR Accelerator (Institute for Evidence-Based Healthcare), RobotReviewer (RobotReviewer), and COVID-NMA (COVID-NMA). Notably, of the 24 tools, only 10 (42%) support direct search, only 7 (29%) offer dual extraction, and only 13 (54%) offer living/updatable reviews. CONCLUSIONS: DistillerSR, Nested Knowledge, and EPPI-Reviewer Web each offer a high density of SR-focused web-based tools. By transparent comparison and discussion regarding SR tool functionality, the medical community can both choose among existing software offerings and note the areas of growth needed, most notably in the support of living reviews.

Design and Feature Analysis of a Thermally Coupled Corona Discharge Air Disinfection Device

The COVID-19 caused by the novel coronavirus is still spreading globally, and blocking its airborne transmission route is of great significance to control the pandemic. The conventional plasma air disinfection devices show advantages in their dynamic and rapid capabilities, but the disinfection performance is limited by a single method, besides, there exists the risk of secondary infection during maintenance. In this work, according to the physiological characteristics of the novel coronavirus, an air disinfection device based on thermally coupled corona discharge was proposed for the improvement of conventional plasma air disinfection technology, which adopted the wire-plate array electrode structure to initiate corona discharge, and utilized heating wires embedded in the collection plate to achieve centralized heating. The discharge para-meters were measured, and a discharge power at stable operation was discovered to be as high as 5.6 W, for which the discharge law was found to obey the Townsend relationship. Measurement and simulation of the thermal parameters showed that, compared with the overall air heating, the efficiency of centralized heating was increased by 17 times, with minimal impact on the ambient temperature. Bacillus amyloliquefaciens and Bacillus subtilis bacteriophages were used as model bacteria and virus to verify the disinfection performance. Results demonstrate that the killing performance is effectively enhanced via thermally coupled corona discharge, with a removal rate of residual virus on the collection plate increasing by 99.97%, thereby reducing the risk of secondary infection. This work lays a device foundation for killing the airborne novel coronavirus, and also provides a technical reference for cutting its airborne transmission. © 2022, High Voltage Engineering Editorial Department of CEPRI. All right reserved.

Epidemic Vulnerability Index for Effective Vaccine Distribution Against Pandemic

As COVID-19 vaccines have been distributed worldwide, the number of infection and death cases vary depending on the vaccination route. Therefore, computing optimal measures that will increase the vaccination effect are crucial. In this paper, we propose an Epidemic Vulnerability Index (EVI) that quantitatively evaluates the risk of COVID-19 based on clinical and social statistical feature analysis of the subject. Utilizing EVI, we investigate the optimal vaccine distribution route with a heuristic approach in order to maximize the vaccine distribution effect. Our main criterias of determining vaccination effect were set with mortality and infection rate, thus EVI was designed to effectively minimize those critical factors. We conduct vaccine distribution simulations with nine different scenarios among multiple Agent-Based Models that were constructed with real-world COVID-19 patients’ statistical data. Our result shows that vaccine distribution through EVI has an average of 5.0% lower in infection cases, 9.4% lower result in death cases, and 3.5% lower in death rates than other distribution methods. © 2021, Springer Nature Switzerland AG.

Software tools to support title and abstract screening for systematic reviews in healthcare: an evaluation.

BACKGROUND: Systematic reviews are vital to the pursuit of evidence-based medicine within healthcare. Screening titles and abstracts (T&Ab) for inclusion in a systematic review is an intensive, and often collaborative, step. The use of appropriate tools is therefore important. In this study, we identified and evaluated the usability of software tools that support T&Ab screening for systematic reviews within healthcare research. METHODS: We identified software tools using three search methods: a web-based search; a search of the online "systematic review toolbox"; and screening of references in existing literature. We included tools that were accessible and available for testing at the time of the study (December 2018), do not require specific computing infrastructure and provide basic screening functionality for systematic reviews. Key properties of each software tool were identified using a feature analysis adapted for this purpose. This analysis included a weighting developed by a group of medical researchers, therefore prioritising the most relevant features. The highest scoring tools from the feature analysis were then included in a user survey, in which we further investigated the suitability of the tools for supporting T&Ab screening amongst systematic reviewers working in medical research. RESULTS: Fifteen tools met our inclusion criteria. They vary significantly in relation to cost, scope and intended user community. Six of the identified tools (Abstrackr, Colandr, Covidence, DRAGON, EPPI-Reviewer and Rayyan) scored higher than 75% in the feature analysis and were included in the user survey. Of these, Covidence and Rayyan were the most popular with the survey respondents. Their usability scored highly across a range of metrics, with all surveyed researchers (n = 6) stating that they would be likely (or very likely) to use these tools in the future. CONCLUSIONS: Based on this study, we would recommend Covidence and Rayyan to systematic reviewers looking for suitable and easy to use tools to support T&Ab screening within healthcare research. These two tools consistently demonstrated good alignment with user requirements. We acknowledge, however, the role of some of the other tools we considered in providing more specialist features that may be of great importance to many researchers.

An application of slow feature analysis to the genetic sequences of coronaviruses and influenza viruses.

BACKGROUND: Mathematical approaches have been for decades used to probe the structure of DNA sequences. This has led to the development of Bioinformatics. In this exploratory work, a novel mathematical method is applied to probe the DNA structure of two related viral families: those of coronaviruses and those of influenza viruses. The coronaviruses are SARS-CoV-2, SARS-CoV-1, and MERS. The influenza viruses include H1N1-1918, H1N1-2009, H2N2-1957, and H3N2-1968. METHODS: The mathematical method used is the slow feature analysis (SFA), a rather new but promising method to delineate complex structure in DNA sequences. RESULTS: The analysis indicates that the DNA sequences exhibit an elaborate and convoluted structure akin to complex networks. We define a measure of complexity and show that each DNA sequence exhibits a certain degree of complexity within itself, while at the same time there exists complex inter-relationships between the sequences within a family and between the two families. From these relationships, we find evidence, especially for the coronavirus family, that increasing complexity in a sequence is associated with higher transmission rate but with lower mortality. CONCLUSIONS: The complexity measure defined here may hold a promise and could become a useful tool in the prediction of transmission and mortality rates in future new viral strains.

A novel perceptual two layer image fusion using deep learning for imbalanced COVID-19 dataset.

BACKGROUND AND PURPOSE: COVID-19 is a new strain of viruses that causes life stoppage worldwide. At this time, the new coronavirus COVID-19 is spreading rapidly across the world and poses a threat to people's health. Experimental medical tests and analysis have shown that the infection of lungs occurs in almost all COVID-19 patients. Although Computed Tomography of the chest is a useful imaging method for diagnosing diseases related to the lung, chest X-ray (CXR) is more widely available, mainly due to its lower price and results. Deep learning (DL), one of the significant popular artificial intelligence techniques, is an effective way to help doctors analyze how a large number of CXR images is crucial to performance. MATERIALS AND METHODS: In this article, we propose a novel perceptual two-layer image fusion using DL to obtain more informative CXR images for a COVID-19 dataset. To assess the proposed algorithm performance, the dataset used for this work includes 87 CXR images acquired from 25 cases, all of which were confirmed with COVID-19. The dataset preprocessing is needed to facilitate the role of convolutional neural networks (CNN). Thus, hybrid decomposition and fusion of Nonsubsampled Contourlet Transform (NSCT) and CNN_VGG19 as feature extractor was used. RESULTS: Our experimental results show that imbalanced COVID-19 datasets can be reliably generated by the algorithm established here. Compared to the COVID-19 dataset used, the fuzed images have more features and characteristics. In evaluation performance measures, six metrics are applied, such as QAB/F, QMI, PSNR, SSIM, SF, and STD, to determine the evaluation of various medical image fusion (MIF). In the QMI, PSNR, SSIM, the proposed algorithm NSCT + CNN_VGG19 achieves the greatest and the features characteristics found in the fuzed image is the largest. We can deduce that the proposed fusion algorithm is efficient enough to generate CXR COVID-19 images that are more useful for the examiner to explore patient status. CONCLUSIONS: A novel image fusion algorithm using DL for an imbalanced COVID-19 dataset is the crucial contribution of this work. Extensive results of the experiment display that the proposed algorithm NSCT + CNN_VGG19 outperforms competitive image fusion algorithms.